Allegra Drug Uses

Allegra is indicated for the relief of symptoms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. Symptoms treated effectively were sneezing, rhinorrhea, itchy nose/palate/throat, itchy/watery/red eyes.

How Taken

Allegra is formulated as a capsule or tablet for oral administration. Allegra is usually taken twice a day, in the morning and the evening. Follow your doctor's instructions. Take each dose with a full glass of water.

Allegra Warnings/Precautions

Do not take Allegra if you have ever had an allergic reaction to it. Before taking this medication, tell your doctor if you have any serious illness such as heart, kidney, or liver disease. You may require a dosage adjustment or special monitoring during treatment if you have other illnesses. Allegra is in the FDA pregnancy category C. This means that it is not known whether Allegra will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether Allegra passes into breast milk. Do not take Allegra without first talking to your doctor if you are breast-feeding a baby. Allegra is not approved for use by children younger than 6 years of age.

Allegra Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Allegra Possible Side Effects

Stop taking Allegra and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). Allergic reactions occur only rarely, and other serious side effects are not likely to occur. Some less serious side effects may be more likely to occur. Continue to take Allegra and talk to your doctor if you experience nausea or an upset stomach. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Allegra Storage

Store Allegra capsules and tablets at controlled room temperature 20-25°C (68-77°F). Foil-backed blister packs containing Allegra capsules and all tablet packaging should be protected from excessive moisture.

Allegra Overdose

Symptoms and signs of Allegra overdose are: dizziness, drowsiness, and dry mouth. Seek emergency medical attention.

More Information

Tell your doctor of all nonprescription and prescription medication you may use, especially: MAO inhibitors, certain blood pressure drugs, digoxin, and all adrenaline-like drugs. Report other drugs which affect the heart rhythm. Ask your doctor or pharmacist for more details. Check the labels carefully on all nonprescription products, such as cough-and-cold medicines that contain antihistamines and decongestants. Consult your pharmacist. Do not take Allegra for several days before any allergy testing since test results can be affected. Do not start or stop any medicine without doctor or pharmacist approval.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Using Pitrakinra to inhibit interleukins-4 and -13 in the lungs may significantly reduce asthma symptoms, according to an article in the medical journal The Lancet, this week's issue.
The authors explain that doctors and scientists have believed for over twenty years that cytokines, such as interleukin-4 or interleukin-13 play a vital role in the onset and development of clinical asthma. However, there has been no scientific evidence that this might be so.
Dr Malinda Longphre, Aerovance Inc, Berkeley, California, USA and team carried out two separate Phase II clinical trials, where patients received Pitrakinra. In the first study 12 volunteers received 25mg of Pitrakinra by subcutaneous injection once per day. The patients in the second study were given either 60mg of Pitrakinra twice a day by nebulization, and another 16 received a placebo. In both trials the volunteers inhaled allergens before and four weeks after treatment - the allergens are designed to induce an asthma attack, the patient during an asthma attack of this type finds it harder to expel air.
The primary endpoint for the first trial was a maximum percentage drop in forced expiratory volume (FEV1)** in one second over 4-10 hours after receiving the allergen. In the second study the primary endpoint was average percentage fall in FEV1 over 4-10 hours after being given the allergen. If smaller falls in FEV1 during the asthma attack for the Pitrakinra group compared to the placebo group were detected, this would indicate that the allergic response had been reduced by Pitrakinra.
In the first study, say the researchers, the maximum percentage fall in FEV1 was 17.1% in the Pitrakinra and 23.1% in the placebo groups - a comparable difference of 26%. In the second study the average percentage drop in FEV1 was 4.4% in the Pitrakinra versus 15.9% in the placebo group - in other words, it was over three and a half times less in the Pitrakinra group.
"The effects of pitrakinra on late phase asthmatic response are promising when compared with similar studies with other successful anti-inflammatory asthma therapies...whether the effect is due to inhibition of interleukin-13 alone, or both interleukin-13 an interleukin-4, is not yet known. Future studies of this drug, as well as molecules that specifically inhibit interleukin-13, in asthmatic individuals of all levels of severity over longer periods of time are clearly warranted," the writers conclude.

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